Reported sightings of a hellish hound and the discovery of newly deaddesiccated corpses bring Sam and Dean Winchester to Brennan, Ohio. But when they catch the monster canine it turns out to be "Frankenmutt"; a reanimated patchwork of pieces from separate dogs.

Soon the brothers are on a trail that leads from mad scientists and biotechnology to a centuries-old alchemists, walking corpses, and an ancient and malevolent power.

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